2016- 中国科学院心理研究所 研究员
2005-2016 中国科学院心理研究所 副研究员,硕士生导师
期间2010年02-10月 费城儿童医院儿童研究中心 访问学者
期间2014年- 博士生导师
2000-2004 中国科学院心理研究所生物心理学专业,获博士学位
1998-2005 中国科学院心理研究所研究实习员、助理研究员
1994-1997 沈阳药科大学药物分析专业,获硕士学位
1990-1994 新疆医学院药学系,获学士学位
应激与精神疾病的心理神经免疫学。结合行为学、遗传学和表观遗传学、分子生物学、显微成像、电生理等方法,研究心理精神疾病相关情绪与认知功能障碍的心理神经免疫机理,发展关键期应激与后期心理病理发病风险的行为学和生物学标记物,发展疾病早期识别和干预的新策略。
2017年- 中国心理学会生理心理学专业委员会 副主任委员
2017年- 中国神经科学学会应激神经生物学分会 副主任委员
2013年- 中国心理卫生协会心身医学专业委员会 委员
2015年- 中国动物学会动物行为学分会理事会 常务理事
2015年- 中国生理学会应激生理学专业委员会 委员
2018年- 中国生理学会中医药脑稳态专业委员会 委员
Brain and behavior 副主编
Frontiers in Molecular Neuroscience 编审
OBM Neurobiology 编委
Stress and Brain 编委
心理学报 编委
代表论著(2015-):
- Xu, Haiyun; Wang, Weiwen; Ellenbroek, Bart; You, Zili. Editorial: Cognitive Dysfunctions in Psychiatric Disorders: Brain-Immune Interaction Mechanisms and Integrative Therapeutic Approaches. Frontiers in Integrative Neuroscience, 2021, 15: 0-649425.
- Ge, Li-Kun; Hu, Zhuoer; Wang, Weiwen; Siu, Parco M.; Wei, Gao-Xia. Aerobic Exercise Decreases Negative Affect by Modulating Orbitofrontal-Amygdala Connectivity in Adolescents. Life-Basel, 2021, 11(6): 0-577.
- Keliang Pang, Richeng Jiang, Wei Zhang, Zhengyi Yang, Lin-Lin Li, Makoto Shimozawa, Simone Tambaro, Johanna Mayer, Baogui Zhang, Man Li, Jiesi Wang, Hang Liu, Ailing Yang, Xi Chen, Jiazheng Liu, Bengt Winblad, Hua Han, Tianzi Jiang, Wang Weiwen, Per Nilsson, Wei Guo, & Lu Bai* (2021). An App knock-in rat model for Alzheimer’s disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments. Cell Research, 32, 157– 175.
- Xu H., Zhang XY, Wang WW, Wang JS. Hydroxychloroquine increased psychiatric-like behaviors and disrupted the expression of related genes in the mouse brain. Frontiers in Pharmacology. 2021, doi: 10.3389/fphar.2021.633112
- Hang Xu, Jiesi Wang, Haiyang Jing, Bart Ellenbroek, Feng Shao, Weiwen Wang*. mPFC GABAergic transmission mediated the role of BDNF signaling in cognitive impairment but not anxiety induced by adolescent social stress, Neuropharmacology, 2021, 184,108412.
- HaoZhou, Jiesi Wang, Yu Zhang, Feng Shao* and Weiwen Wang*. The Role of Microglial CX3CR1 in Schizophrenia-Related Behaviors Induced by Social Isolation. Frontiers in Integrative Neuroscience. September 2020, Volume14: Article 551676.
- Qiong Wang, Yingjuan Liu, Jianxu Zhang* and Weiwen Wang*. Corticotropin-Releasing Factor Receptors in the Locus Coeruleus Modulate the Enhancement of Active Coping Behaviors Induced by Chronic Predator Odor Inoculation in Mice. Frontiers in Psychology. 2020, 10: 3028.
- Yuanyuan Xin, Zhuxi Yao, Weiwen Wang, Yuejia Luo, Andr_e Aleman and Jianhui Wu. Recent life stress predicts blunted acute stress response and the role of executive control. STRESS. 2020, VOL. 23(3): 359–367.
- Yu Zhang, Hang Xu, Jiesi Wang, Fengyan Ren,b, Feng Shao, Bart Ellenbroek, Wenjuan Lin, Weiwen Wang. (2019). Transient upregulation of immune activity induced by adolescent social stress is involved in cognitive deficit in adult male mice and early intervention with minocycline. Behavioral Brain Research, 374, 112136, doi.org/10.1016/j.bbr.2019.112136
- Yu Zhang#, Hang Xu#, Fan Zhang, Feng Shao, Bart Ellenbroek, Jiesi Wang*, Weiwen Wang*. (2019). Deficiencies of microglia and TNFa in the mPFC-mediated cognitive inflexibility induced by social stress during adolescence. Brain, behavior and immunity, 79, 256-266.
- Wang, W., Wang, L*., Xu, H., Cao, C., Liu, P., Luo, S., . . . Zhang, X. (2019). Characteristics of pro- and anti-inflammatory cytokines alteration in PTSD patients exposed to a deadly earthquake. J Affect Disord, 248, 52-58. doi: 10.1016/j.jad.2019.01.029
- Man Li; Weiwen Wang#; Lan Sun; Wei Du; Hao Zhou; Feng Shao*, (2019). Chronic clozapine treatment improves the alterations of prepulse inhibition and BDNF mRNA expression in the medial prefrontal cortex that are induced by adolescent social isolation. Behavioural Pharmacology. 30(4):311–319
- Xin, Y., Yao, Z., Wang, W., Luo, Y., Aleman, A., Wu, J. (2019). Recent life stress predicts blunted acute stress response and the role of executive control. Stress, 12:1-9. doi.org/10.1080/10253890.2019.1687684
- Zheng Chen, Quan Zhang, Shenghuo Chen, Weiwen Wang, Guoxiong Liu, Huihua Deng. (2019). Determination, intercorrelation and intraindividual stability of five steroids in hair, saliva and urine among chinese college students. Steroids, 149, 108418
- Li, M., Xu, H., & Wang, W. * (2018). An Improved Model of Physical and Emotional Social Defeat: Different Effects on Social Behavior and Body Weight of Adolescent Mice by Interaction With Social Support. Frontiers in Psychiatry, 9(688). doi: 10.3389/fpsyt.2018.00688
- Hang Xu#, Jiesi Wang#, Ke Zhang, Mei Zhao, Bart Ellenbroek, Feng Shao*, Weiwen Wang*. Effects of adolescent social stress and antidepressant treatment on cognitive inflexibility and Bdnf epigenetic modifications in the mPFC of adult mice. Psychoneuroendocrinology, 2018, 88: 92-101.
- Zhang, Q., Chen, Z., Chen, S., Yu, T., Wang, J., Wang, W., & Deng, H. (2018). Correlations of hair level with salivary level in cortisol and cortisone. Life Sci, 193, 57-63. doi: 10.1016/j.lfs.2017.11.037
- Qiong Wang, Feng Shao and Weiwen Wang*. Region-Dependent Alterations in Cognitive Function and ERK1/2 Signaling in the PFC in Rats after Social Defeat Stress. Neural Plasticity, 2018, doi.org/10.1155/2018/9870985
- Sun, Lan, Min, Li, Li, Man, Shao, Feng*, & Wang, Weiwen* (2018). Transcriptomic analysis reveals oxidative phosphorylation activation in an adolescent social isolation rat model. BRAIN RESEARCH BULLETIN,142,304-312.
- Bart A. Ellenbroek, Weiwen Wang. The Translational Umbrella - A Novel Approach to the Study of the Biological Basis of Mental Health. OBM Neurobiology, 2018; 2(1), doi: 10.21926/obm.neurobiol.1801008
- Lan Sun, Li Min, Hao Zhou, Man Li, Feng Shao*, Weiwen Wang*, Adolescent social isolation affects schizophrenia-like behavior and astrocyte biomarkers in the PFC of adult rats. Behav Brain Res, 2017, 333: p. 258-266.
- Zhang, Y., Shao, F., Wang, Q., Xie, X., Wang, W.W. * (2017). Neuroplastic correlates in the mPFC underlying the impairment of stress-coping ability and cognitive flexibility in adult rats exposed to chronic mild stress during adolescence. Neural Plasticity, 10. doi: 10.1155/2017/9382797
- Jenny Berrío, Weiwen Wang, Bart A. Ellenbroek. Perspectives on the Neurobiology of Antipsychotic Drugs in Psychiatric Disorders. OBM Neurobiology.2017,1(1): doi:10.21926/obm.neurobiol.1701001
- 徐 航,陈焕新,王玮文*. GABA 能系统在应激诱发的抑郁症中的作用.心理科学进展. 2017, 25(12): 2075–2081
- 张 瑜,林文娟,王玮文*. 中枢免疫失衡与认知功能障碍:聚焦TNF的作用.心理科学进展. 2017, 25(12): 2036–2042
- 王琼,王玮文*,李曼,杜伟,邵枫*.阻断内侧前额叶皮质TrkB受体对大鼠认知和海马BDNF表达的影响. 2016, 48(5): 509-517.
- Xu, H. #, Zhang, Y. #, Zhang, F., Yuan, S., Shao, F., & Wang, W. * (2016). Effects of Duloxetine Treatment on Cognitive Flexibility and BDNF Expression in the mPFC of Adult Male Mice Exposed to Social Stress during Adolescence. Frontiers in Molecular Neuroscience, 9, 95.
- Zhang, F.#, Yuan, S. #, Shao, F., & Wang, W.W. * (2016). Adolescent social defeat induced alterations in social behavior and cognitive flexibility in adult mice: effects of developmental stage and social condition. Frontiers in Behavioral Neuroscience, 10, 149,1-11.
- Li, M., Du, W., Shao, F. *, Wang, W.W. * (2016). Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence. Behav Brain Res, 313, 177-183.
- Mwanza, C., Chen, Z., Zhang, Q., Chen, S., Wang, W. W., & Deng, H.H. * (2016). Simultaneous HPLC-APCI-MS/MS quantification of endogenous cannabinoids and glucocorticoids in hair. Journal of Chromatography B, 1028, 1-10.
- 张权,陈崝,王玮文,邓慧华.创伤后应激障碍患者的HPA轴功能变化的时间序列特征. 《心理科学进展》, 2016,24(4):536-546
- Tian Yu, Hang Xu, Weiwen Wang, Shifei Li, Zheng Chen, Huihua Deng*. Determination of endogenous corticosterone in rodent’s blood, brainand hair with LC–APCI–MS/MS. Journal of Chromatography B, 2015, 1002: 267–276
- Qiong Wang, Feng Shao*, Weiwen Wang*. Maternal separation produces alterations of forebrain brain-derived neurotrophic factor expression in differently aged rats. Frontiers in Molecular Neuroscience. 2015,8:49:1-9
- Weiwen Wang, Huihua Deng, Li Wang*, Chengqi Cao,Hang Xu, Jianxin Zhang. Hair cortisone level is associated with PTSD’s dysphoric arousal symptoms in highly traumatized Chinese females. Journal of affective disorders, 2015, 182, 18-22
- Yan Jin, Bin Luo, Yan-Yan Su,Xin-Xing Wang, Liang Chen*, Ming, Wang, Wei-Wen*, Lin Chen*. Sodium salicylate suppresses GABAergic 1 inhibitory activity in neurons of rodent dorsal raphe nucleus. Plos one, 2015, 10(5): e0126956.
- Qiong Wang, Man Li, Wei Du, Feng Shao*, Weiwen Wang*. The different effects of maternal separation on spatial learning and reversal learning in rats. Behavioural Brain Research, 2015, 280: 16–23.
译/编著作:
1、王福顺等,情绪心理学(第四章情绪的生理机制)(全国高等学校教材国家卫生健康委员会“十三五”规划教材). 人民卫生出版社,2018
2、行为的生物心理学基础,苏彦捷等著,应激与健康(第九章)
3、詹姆斯.卡拉特著,苏彦捷等译,生物心理学 (第十版)(第十章).人民邮电出版社,2011.
专利和软著:
1、 王玮文, 张伟, 井海洋, & 王杰思. (2020). 一种基于触屏操作箱视觉空间配对学习的实验与分析方法. CN111990971A.(发明专利)CN202010912439.7
2、 中国科学院心理研究所(王玮文,张伟,井海洋). 基于一种触屏操作箱内的视觉空间配对学习过程的数据提取和精细化分析软件 V1.0. 软件著作权登记证书. 2020SR1162221.
3、 王玮文,张瑜,任凤燕;米诺环素用于制备精神疾病相关认知功能障碍早期干预药物的用途(CN110151772A)CN201910401486.2
4、 王玮文;林文娟;邵枫;杨震.一种多水平客观测定动物学习能力的行为实验系统和方法. 中国, 2005 1 0086956.9(发明专利)
5、 王玮文;林文娟;邵枫;杨震.一种动物学习能力的行为测试用的水迷宫.中国, 200520142005.4(实用新型
6、 王玮文; 梁云明;黄景新.一种适于同时蒸发多个液态生化样品的干燥装置FPI03034(发明专利)
- 国家自然科学基金项目面上项目,“小胶质细胞在青少期创伤后不同情绪障碍发展风险中的异质性作用及其神经可塑性机制”(82071517),2021.1-2024.12,主持
- 国家重点研发计划政府间国际科技创新合作重点专项课题,“神经营养因子参与神经退行性疾病的环路及机制研究”(2017YFE0126500),2019.8-2022,7,课题负责
- 中国科学院心理研究所开放课题,“AMPA受体GluA1亚基在创伤后应激障碍负性情绪的发生及靶向干预中的作用研究”,2021.1-2023.12,合作者
- 国家自然科学基金项目面上项目,“青少期应激诱发抑郁症认知功能障碍的中枢免疫机制及干预新策略”(31771217),2018.1-2021.12, 61万,主持
- 心理健康院重点实验室重点课题,“注意缺陷多动障碍模型大鼠内侧前额皮层-伏隔核环路在决策冲动性中的作用机制”(KLMH2020K06),2020.09-2022.09,合作者
- 国家自然科学基金项目面上项目,“青少期早期社会应激对抑郁样行为和前额叶GABA能系统的影响及其关系研究”(81471122), 2015/01-2018/12, 主持
- 中国科学院“十二五”重点部署项目,“中国特定人群的心理与社会行为研究”子课题“ 创伤后应激障碍临床异质性的心理神经机制” KSZD-EW-Z-008),2013/01-2016/12,参与
- 心理健康院重点实验室重点课题,“创伤后应激障碍患者HPA轴功能变化的时间序列特征”(KLMH2015K01),2014.1-2016.12,合作者
- 心理健康院重点实验室重点课题,“早年创伤诱导快感缺失样抑郁行为的奖赏环路机制”,2016/01-2018/12,合作者
- 中国科学院心理研究所自主部署科研项目 “重性抑郁症的功能分型及神经基础研究”(Y5CX152008),2015.11-2017.11,主要成员
- 国家自然科学基金项目重大研究计划培育项目,“应激影响青少年情绪和认知发展的BDNF调控机制及早期干预研究”(91132728), 2012/01-2014/12, 主持