2017.01- 中国科学院心理研究所 研究员
2005.02-2016.12 中国科学院心理研究所 副研究员,硕士生导师
(其间2010年02-10月 费城儿童医院儿童研究中心 访问学者)
(其间2014年- 博士生导师)
2000.09-2004.06 中国科学院心理研究所生物心理学专业,获博士学位
1998.08-2005.02 中国科学院心理研究所研究实习员、助理研究员
1994.09-1997.06 沈阳药科大学药物分析专业,获硕士学位
1990.09-1994.06 新疆医学院药学系,获学士学位
目前作为国内最早建立也是唯一的心理神经免疫学实验室负责人,课题组主要采用行为学,药物学,遗传学,分子生物学,显微成像和电生理等多种技术,开展创伤及应激相关精神障碍的心理神经免疫学基础与临床研究,尤其关注早期经历对心理行为、脑和生理(尤其免疫)发育的影响及其健康与疾病后果。
团队与国际心理神经免疫学研究学会(PNIRS)密切合作,在免疫精神病学研究,PNI学科推广与国际交流方面发挥积极引领作用。研究工作持续获得国自然、科技部、中国科学院、心理研究所、心理健康院重点实验室基金项目资助,相关工作在Biological psychiatry, Research,Neuropsychopharmacology, Brain, Behavior and Immunity, Cell Research, Neurobiology of Disease,心理学报等领域内重要学术期刊发表。
现任中国心理学会生理心理学专委会副主任委员;中国神经科学学会应激神经生物学分会副主任委员;中国生理学会应激生理学分会委员;担任心理神经免疫学领域旗舰期刊Brain, Behavior and Immunity副主编;Brain, Behavior and Immunity-Integrative 创刊副主编;Brain and behavior 副主编;Neurobiology of stress、心理学报,Stress and Brain等期刊编委。
2017年- 中国心理学会生理心理学专业委员会 副主任委员
2017年- 中国神经科学学会应激神经生物学分会 副主任委员
2022年- 中国心理学会神经心理学专业委员会委员
2018年- 中国生理学会应激生理学专业委员会 委员
2018年- 中国生理学会中医药脑稳态专业委员会 委员
2023.08- Brain, Behavior and Immunity 副主编
2018.03- Brain and behavior 副主编
2022.12- Brain, Behavior and Immunity-Integrative 创刊副主编
2022.12- Neurobiology of stress 编委
2022.02- 心理学报 编委
2022.06- Life 编委
2018.03- OBM Neurobiology 编委
2019.10- Stress and Brain 编委
2022.12- Neurobiology of stress 编委
主要发表
Linan Zhuo, Keliang Pang, Jiajie Dai, Bing Wu, Jiesi Wang, Hang Xu, Shuming Yang, Ziao Liu, Rongrong Niu, Ping Yu**, Weiwen Wang. The neurophysiological mechanisms of medial prefrontal-perirhinal cortex circuit mediating temporal order memory decline in early stage of AD rats. Neurobiology of Disease 199 (2024) 106584
Mingyue Zhao, Xueping Xu, Hang Xu, Shuming Yang, Man Li, Weiwen Wang. The regulation of social factors on anxiety and microglial activity in nucleus accumbens of adolescent male mice: Influence of social interaction strategy. Journal of Affective Disorders 352 (2024) 525–535.
Xu, H., Li, M., Cai, J., Yuan, Y., He, L., Liu, J., ... & Wang, W. (2023). Comparison of ACE-IQ and CTQ-SF for child maltreatment assessment: Reliability, prevalence, and risk prediction. Child Abuse & Neglect, 146, 106529
Mingyue Zhao#, Jiajie Dai#, Hang Xu, Yu Zhang*, Weiwen Wang*. mPFC TNFR2 modulated the impairment of cognitive flexibility induced by adolescent social stress and the relevant neuroplastic molecules. Brain Behavior and Immunity Integrative, 2023. doi:https://doi.org/10.1016/j.bbii.2023.100032
Wang Jiesi, Zhang Wei, Xu Hang, Bart Ellenbroek, Dai Jiajie, Wang Li, Yan Chaogan, Wang Weiwen. The Changes of Histone Methylation Induced by Adolescent Social Stress Regulate the Resting-State Activity in mPFC. Research. 2023;6:Article0264. https://doi.org/10.34133/research.0264
戴佳婕,赵明月,&王玮文.(2023).创伤后应激障碍共病抑郁的神经生物学研究进展. 中华行为医学与脑科学杂志, 2023, 32,1-7
卓利楠,曾祥玉,吴冰,牛荣荣,于萍,王玮文. 内侧前额皮层−伏隔核环路在决策冲动中的作用:基于动物模型的研究. 心理学报 2023, Vol. 55, No. 3, 1-16
Weiwen Wang, Wenjuan Lin, Gang Chen, Zili You. History and main research of psychoneuroimmunology in China. Brain, Behavior, & Immunity - Health 26 (2022) 100562
Keliang Pang, Richeng Jiang, Wei Zhang, Zhengyi Yang, Lin-Lin Li, Makoto Shimozawa, Simone Tambaro, Johanna Mayer, Baogui Zhang, Man Li, Jiesi Wang, Hang Liu, Ailing Yang, Xi Chen, Jiazheng Liu, Bengt Winblad, Hua Han, Tianzi Jiang, Wang Weiwen, Per Nilsson, Wei Guo, & Lu Bai* (2021). An App knock-in rat model for Alzheimer’s disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments. Cell Research, 32, 157– 175.
Xu H., Zhang XY, Wang WW, Wang JS*. Hydroxychloroquine increased psychiatric-like behaviors and disrupted the expression of related genes in the mouse brain. Frontiers in Pharmacology. 2021, doi: 10.3389/fphar.2021.633112
Hang Xu, Jiesi Wang, Haiyang Jing, Bart Ellenbroek, Feng Shao, Weiwen Wang*. mPFC GABAergic transmission mediated the role of BDNF signaling in cognitive impairment but not anxiety induced by adolescent social stress, Neuropharmacology, 2021, 184,108412.
Wei Du, Man Li, Hao Zhou, Feng Shao*, Weiwen Wang*. (2021). Alteration of the PKA-CREB cascade in the mPFC accompanying prepulse inhibition deficits: evidence from adolescent social isolation and chronic SKF38393 injection during early adolescence. Behav Pharmacol., 2021, 32(6): 487-496. doi: 10.1097/FBP.0000000000000643
Yu Zhang, Hang Xu, Jiesi Wang, Fengyan Ren,b, Feng Shao, Bart Ellenbroek, Wenjuan Lin, Weiwen Wang⁎. (2019). Transient upregulation of immune activity induced by adolescent social stress is involved in cognitive deficit in adult male mice and early intervention with minocycline. Behavioral Brain Research, 374, 112136, doi.org/10.1016/j.bbr.2019.112136
Yu Zhang, Hang Xu, Fan Zhang, Feng Shao, Bart Ellenbroek, Jiesi Wang, Weiwen Wang. (2019). Deficiencies of microglia and TNFa in the mPFC-mediated cognitive inflexibility induced by social stress during adolescence. Brain, behavior and immunity, 79, 256-266.
Wang, W., Wang, L*., Xu, H., Cao, C., Liu, P., Luo, S., . . . Zhang, X. (2019). Characteristics of pro- and anti-inflammatory cytokines alteration in PTSD patients exposed to a deadly earthquake. J Affect Disord, 248, 52-58. doi: 10.1016/j.jad.2019.01.029
Man Li; Weiwen Wang#; Lan Sun; Wei Du; Hao Zhou; Feng Shao*, (2019). Chronic clozapine treatment improves the alterations of prepulse inhibition and BDNF mRNA expression in the medial prefrontal cortex that are induced by adolescent social isolation. Behavioural Pharmacology. 30(4):311–319
Zheng Chen, Quan Zhang, Shenghuo Chen, Weiwen Wang, Guoxiong Liu, Huihua Deng. (2019). Determination, intercorrelation and intraindividual stability of five steroids in hair, saliva and urine among chinese college students. Steroids, 149, 108418
Li, M.#, Xu, H.#, & Wang, W. * (2018). An Improved Model of Physical and Emotional Social Defeat: Different Effects on Social Behavior and Body Weight of Adolescent Mice by Interaction With Social Support. Frontiers in Psychiatry, 9(688). doi: 10.3389/fpsyt.2018.00688
Hang Xu, Jiesi Wang, Ke Zhang, Mei Zhao, Bart Ellenbroek, Feng Shao, Weiwen Wang. Effects of adolescent social stress and antidepressant treatment on cognitive inflexibility and Bdnf epigenetic modifications in the mPFC of adult mice. Psychoneuroendocrinology, 2018, 88: 92-101.
Lan Sun, Li Min, Hao Zhou, Man Li, Feng Shao*, Weiwen Wang*, Adolescent social isolation affects schizophrenia-like behavior and astrocyte biomarkers in the PFC of adult rats. Behav Brain Res, 2017, 333: p. 258-266.
徐 航, 陈焕新, 王玮文*. GABA 能系统在应激诱发的抑郁症中的作用. 心理科学进展. 2017, 25(12): 2075–2081
张 瑜,林文娟,王玮文*. 中枢免疫失衡与认知功能障碍:聚焦TNF的作用. 心理科学进展. 2017, 25(12): 2036–2042
王琼,王玮文*,李曼,杜伟,邵枫*. 阻断内侧前额叶皮质TrkB受体对大鼠认知和海马BDNF表达的影响. 2016, 48(5): 509-517.
Xu, H., Zhang, Y., Zhang, F., Yuan, S., Shao, F., & Wang, W. (2016). Effects of Duloxetine Treatment on Cognitive Flexibility and BDNF Expression in the mPFC of Adult Male Mice Exposed to Social Stress during Adolescence. Frontiers in Molecular Neuroscience, 9, 95.
Zhang, F., Yuan, S., Shao, F., & Wang, W.W. (2016). Adolescent social defeat induced alterations in social behavior and cognitive flexibility in adult mice: effects of developmental stage and social condition. Frontiers in Behavioral Neuroscience, 10, 149,1-11.
Li, M., Du, W., Shao, F. , Wang, W.W. (2016). Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence. Behav Brain Res, 313, 177-183.
Mwanza, C., Chen, Z., Zhang, Q., Chen, S., Wang, W. W., & Deng, H.H. (2016). Simultaneous HPLC-APCI-MS/MS quantification of endogenous cannabinoids and glucocorticoids in hair. Journal of Chromatography B, 1028, 1-10.
张权,陈崝,王玮文,邓慧华.创伤后应激障碍患者的HPA轴功能变化的时间序列特征. 《心理科学进展》, 2016,24(4):536-546
Tian Yu, Hang Xu, Weiwen Wang, Shifei Li, Zheng Chen, Huihua Deng. Determination of endogenous corticosterone in rodent’s blood, brainand hair with LC–APCI–MS/MS. Journal of Chromatography B, 2015, 1002: 267–276
Weiwen Wang, Huihua Deng, Li Wang*, Chengqi Cao,Hang Xu, Jianxin Zhang. Hair cortisone level is associated with PTSD’s dysphoric arousal symptoms in highly traumatized Chinese females. Journal of affective disorders, 2015, 182, 18-22
Qiong Wang, Man Li, Wei Du, Feng Shao, Weiwen Wang. The different effects of maternal separation on spatial learning and reversal learning in rats. Behavioural Brain Research, 2015, 280: 16–23.
Li Wang, Chengqi Cao, Weiwen Wang*, Hang Xu, Jianxin Zhang, Huihua Deng, Xiangyang Zhang. Linking hair cortisol levels to phenotypic heterogeneity of posttraumatic stress symptomatology in highly traumatized Chinese females. Biological Psychiatry. 2015; 77 :e21–e22
原三娜;罗晓敏;张帆;邵枫;王玮文*. 大鼠注意定势转移任务模型的深入研究:种系和检测程序的影响. 心理学报,2014,46(12):1-9
Xi-ting Guan, Feng Shao, Xi Xie, Lin Chen, Weiwen Wang*. Effects of aspirin on immobile behavior and endocrine and immune changes in the forced swimming test: comparison to fluoxetine and imipramine. Pharmacology, Biochemistry and Behavior. 2014, 124:361-366
Xiao-Min Luo, San-Na Yuan, Xi-Ting Guan, Xi Xie, Feng Shaoc, Wei-Wen Wang*. Juvenile stress affects anxiety-like behavior and limbic monoamines in adult rats. Physiology & Behavior 135 (2014) 7–16
张 帆, 雍 武, 邵 枫, 王玮文*. 中枢肥大细胞在脑功能和行为调节中的作用. 心理科学进展 2014,22(9): 1–11
薛晓芳, 李曼,王玮文,邵枫.母婴分离的动物模型及其神经生物学机制. 心理科学进展, 2013, 21(6): 990-998.
Xue X., Shao S.,Wang W. *, Shao F. Maternal Separation Induces Alterations in Reversal Learning and Brain-Derived Neurotrophic Factor Expression in Adult Rats. Neuropsychobiology 2013;68:243-24
Kevin Snyder, Wei-Wen Wang#, Rebecca Han, Kile McFadden and Rita J. Valentino.Corticotropin-releasing Factor in the Norepinephrine Nucleus, Locus Coeruleus, Facilitates Cognitive Flexibility. Neuropsychopharmacology, 2011, 1–11.
Han, X., Li, N., Meng, Q., Shao F.*, Wang, W. Maternal Immune Activation Impairs Reversal Learning and Increases Serum Tumor Necrosis Factor-α in Offspring. Neuropsychobiology, 2011,64(1): 9-14
Meng, Q., Li, N., Han, X., Shao, F., & Wang, W. Effects of adolescent social isolation on the expression of brain-derived neurotrophic factors in the forebrain. European Journal of Pharmacology, 2011, 650(1): 229-232
Shao, F., Han, X., Li, N., & Wang, W*. Adolescent chronic apomorphine treatment impairs latent inhibition and reduces prefrontal cortex mGluR5 receptor expression in adult rats.. European Journal of Pharmacology, 2010, 649(1-3), 202-205.
Meng, Q., Li, N., Han, X., Shao, F.*, & Wang, W*. Peri-adolescence isolation rearing alters social behavior and nociception in rats. Neuroscience Letters, 2010, 480(1), 25-29.
Feng Shao, Jian Jin, Qingxuan Meng, Mei Liu, Xi Xie, Wenjuan Lin, Weiwen Wang*. Pubertal isolation alters latent inhibition and DA in nucleus accumbens of adult rats. Physiology & behavior, 2009, 98:251-257
获奖
刘平,王力,曹成琦,张昆林,王玮文,张红。DSM-5 PTSD症状诊断模型的构建。德阳市人民医院,中国科学院心理研究所。四川省科技进步三等奖, 2022
译/编著作
王福顺等,情绪心理学(第四章情绪的生理机制)(全国高等学校教材国家卫生健康委员会“十三五”规划教材). 人民卫生出版社,2018年7月
行为的生物心理学基础,苏彦捷等著,应激与健康(第九章)
詹姆斯.卡拉特著,苏彦捷等译,生物心理学 (第十版)(第十章).人民邮电出版社,2011
专利和软著
王玮文, 张伟, 井海洋, 王杰思. 一种基于触屏操作箱视觉空间配对学习的实验与分析方法. 发明专利号:CN111990971A,申请号:CN202010912439.7,2020-9-2,授权公告号:CN 111990971 B,20230707
王玮文,张伟,井海洋. 基于一种触屏操作箱内的视觉空间配对学习过程的数据提取和精细化分析软件 V1.0. 软件著作权登记证书. 登记号:2020SR1162221. 登记日:2020-9-25
王玮文;林文娟;邵枫;杨震. 一种多水平客观测定动物学习能力的行为实验系统和方法. 中国, 2005 1 0086956.9(发明专利)
王玮文;林文娟;邵枫;杨震.一种动物学习能力的行为测试用的水迷宫.中国, 200520142005.4(实用新型)
国家自然科学基金区域创新发展联合基金重点支持项目,“COVID-19相关的创伤后应激障碍的发病机制及干预策略研究”,2022.01-2025.12
国家自然科学基金项目面上项目,“小胶质细胞在青少期创伤后不同情绪障碍发展风险中的异质性作用及其神经可塑性机制”,2021.1-2024.12
国家重点研发计划政府间国际科技创新合作重点专项课题,“神经营养因子参与神经退行性疾病的环路及机制研究”,2019.8-2022,7
国家自然科学基金项目面上项目,“青少期应激诱发抑郁症认知功能障碍的中枢免疫机制及干预新策略”, 2018.1-2021.12
国家自然科学基金项目面上项目,“青少期早期社会应激对抑郁样行为和前额叶GABA能系统的影响及其关系研究”, 2015.01-2018.12
中国科学院“十二五”重点部署项目, “中国特定人群的心理与社会行为研究”子课题“ 创伤后应激障碍临床异质性的心理神经机制”, 2013.01-2016.12
国家自然科学基金项目重大研究计划培育项目,“应激影响青少年情绪和认知发展的BDNF调控机制及早期干预研究”, 2012.01-2014.12